Lactobacillus plantarum HY7715의 근육량과 근기능 향상을 통한 노령 쥐 모델의 근감소증 개선 효과
Abstract: Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially
impacts a person’s quality of life. Recent studies to improve muscle function through the intake of various functional food materials are attracting attention. However, it is not yet known whether probiotics can
improve muscle mass and muscle strength and affect physical performance.
Lactobacillus plantarum HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The presentresearch shows that L. plantarum HY7715 increases physical performance and skeletal muscle mass
in 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrial biogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715 recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as a functional probiotic supplement to improve the degeneration of muscle function that is associated with aging.