[HY7715] Research paper_ Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice 2021-09-23 최고관리자 0 197 2021.09.23 15:38 Abstract: Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physicalfrailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantiallyimpacts a person’s quality of life. Recent studies to improve muscle function through the intakeof various functional food materials are attracting attention. However, it is not yet knownwhether probiotics can improve muscle mass and muscle strength and affect physical performance.Lactobacillus plantarum HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The presentresearch shows that L. plantarum HY7715 increases physical performance and skeletal muscle massin 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrialbiogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as afunctional probiotic supplement to improve the degeneration of muscle function that is associatedwith aging.