[hy Fermented Red Ginseng] Research Paper _ Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng
Background: It is well recognized that gut microbiota is involved in the biotransformation of ginsenosides
gut microbiota on the pharmacokinetics of ginsenosides in humans have not yet been fully elucidated.
(CK)eforming activities were measured. Then, the correlations between the pharmacokinetic profiles of
Results: For the RG group, the area under the serum concentrationetime curve values of ginsenosides Rd,
40.30 29.83 ng$h/mL, respectively. For the fermented red ginseng group, the the area under curve from
30.24 41.87 ng$h/mL, 28.68 14.27 ng$h/mL, and 137.01 96.16 ng$h/mL, respectively. The fecal CKforming
activities. The area under the serum concentrationetime curve value of CK exhibited an obvious positive